LINZESS is structurally related to human uroguanylin and guanylin, and is metabolized into smaller peptides and naturally occurring amino acids.1
LINZESS acts on GC-C receptors throughout
the upper and lower GI tract, across the entire pH range
The clinical relevance of the effect on nerve fibers has not been established.
LINZESS ACTS LOCALLY1
*No drug-drug interaction studies have been conducted with LINZESS, but no systemic drug-drug
interactions are anticipated.
Exposures of drug and active metabolite are negligible following oral medication.
Based on nonclinical studies.
LINZESS is the #1 prescribed brand by gastroenterologists19