Once-daily LINZESS is a capsule taken orally to help patients proactively manage their symptoms1
LINZESS is approved to treat adult men and women with Irritable Bowel Syndrome with Constipation (IBS-C) or Chronic Idiopathic Constipation (CIC).1 Over 1 million patients have filled prescriptions for LINZESS.*
*IMS Health, Total Patient Tracker, November 2012-December 2016.
Capsules shown not actual size.
There's more than one way to take LINZESS. Now adult patients who have trouble swallowing capsules can open the LINZESS capsule and 1:
- Sprinkle on applesauce, or
- Add to water, or
- Mix with water and administer via a nasogastric or gastrostomy tube
Please see full Prescribing Information for complete Dosage and Administration Information.
‡IMS Health, NPA Audit, January 2015-December 2016.
- Store at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. It is important to keep LINZESS in the original container. Do not subdivide or repackage. Protect from moisture. Do not remove desiccant from the container. Keep bottles tightly closed in a dry place1
- No drug-drug interaction studies have been conducted with LINZESS. Linaclotide and its active metabolite are not measurable in plasma following administration of the recommended clinical doses; hence, no systemic drug-drug interactions or drug interactions mediated by plasma protein binding of linaclotide or its metabolite are anticipated1
- Linaclotide does not interact with the cytochrome P450 enzyme system based on the results of in vitro studies1
Use in Specific Populations
- Linaclotide and its active metabolite are negligibly absorbed systemically following oral administration, and maternal use is not expected to result in fetal exposure to the drug. The available data on LINZESS use in pregnant women are not sufficient to inform any drug-associated risk for major birth defects and miscarriage1
- There is no information regarding the presence of linaclotide in human milk, or on its effects on milk production or the breastfed infant. No lactation studies in animals have been conducted1