Once-daily LINZESS is a capsule taken orally to help patients proactively manage their symptoms1
LINZESS is approved to treat adult men and women with Irritable Bowel Syndrome with Constipation (IBS-C) or Chronic Idiopathic Constipation (CIC).1 Over 1 million patients have filled prescriptions for LINZESS.*
*IMS Health, Total Patient Tracker, November 2012-December 2015.
Capsules shown not actual size.
†IMS Health, NPA Audit, January 2015-December 2015.
There’s more than one way to take LINZESS. Now adult patients who have trouble swallowing capsules can open the LINZESS capsule and1:
- Sprinkle into applesauce
- Add to a glass of water
- Mix with water and add to a feeding tube
Please see full Prescribing Information for important administration instructions.
- Store at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. It is important to keep LINZESS in the original container. Do not subdivide or repackage. Protect from moisture. Do not remove desiccant from the container. Keep bottles tightly closed in a dry place1
- No drug-drug interaction studies have been conducted with LINZESS. Linaclotide and its active metabolite are not measurable in plasma following administration of the recommended clinical doses; hence, no systemic drug-drug interactions or drug interactions mediated by plasma protein binding of linaclotide or its metabolite are anticipated1
- Linaclotide does not interact with the cytochrome P450 enzyme system based on the results of in vitro studies1
Use in specific populations
- Pregnancy Category C: There are no adequate and well-controlled studies with LINZESS in pregnant women. LINZESS should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus1
- It is not known whether linaclotide is excreted in human milk; however, linaclotide and its active metabolite are not measurable in plasma following administration of the recommended clinical doses. Caution should be exercised when LINZESS is administered to nursing women1